Non-invasive assessment of interstitial myocardial fibrosis in pressure-overload left ventricular hypertrophy
نویسندگان
چکیده
Non-invasive assessment of interstitial myocardial fibrosis in pressure-overload left ventricular hypertrophy Andrew Jabbour, Tevfik F Ismail, Sofia V De Noronha, Carl Shakespeare, Sameer Zaman, Oluwatosin Sotubo, Saman S Zaman, Callum Ettles, Benjamin Hewins, Rick Wage, Ankur Gulati, Pedro F Ferreira, Pierre Croisille, Yanqiu Feng, Katsuya Norita, Raad H Mohiaddin, Taigang He, John Pepper, David N Firmin, Mary Sheppard, Dudley J Pennell, Mario Petrou, Sanjay K Prasad
منابع مشابه
Minimally invasive aortic banding in mice: Effects of altered cardiomyocyte insulin signaling during pressure-overload Running Title: Minimally invasive aortic banding and insulin signaling
We have developed a minimally invasive method for producing left ventricular pressure-overload in mice. Using this technique we quickly and reproducibly banded the transverse aorta with low surgical morbidity and mortality. Minimally invasive transverse aortic banding (MTAB) acutely and chronically increased left ventricular (LV) systolic pressure, increased heart weight/body weight and induced...
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متن کاملMinimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload.
We developed a minimally invasive method for producing left ventricular (LV) pressure overload in mice. With the use of this technique, we quickly and reproducibly banded the transverse aorta with low surgical morbidity and mortality. Minimally invasive transverse aortic banding (MTAB) acutely and chronically increased LV systolic pressure, increased heart weight-to-body weight ratio, and induc...
متن کاملInterstitial expansion in pressure overload left ventricular hypertrophy
Background Diffuse myocardial fibrosis (DMF) is an important factor in cardiac disease, but until recently could only be accurately assessed with biopsy. We hypothesised that DMF measured by Equilibrium contrast CMR (EQ-CMR) is elevated in cardiac pressure overload (hypertension and aortic stenosis), that the degree of DMF will track the clinical severity of pressure overload and cardiac effect...
متن کاملLow coronary perfusion pressure is associated with endocardial fibrosis in a rat model of volume overload cardiac hypertrophy.
UNLABELLED Left ventricular hypertrophy following volume overload is regarded as an example of cardiac remodeling without increased fibrosis accumulation. However, infarction is associated with increased fibrosis within the noninfarcted, hypertrophied myocardium, particularly in the subendocardial regions. It is conceivable to suppose that, as also occurs postinfarction, low coronary driving pr...
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